PAI-1 may represent an integral molecule in the quick connection/detachment occasions necessary for cell migration, by its capability to both lower its affinity for vitronectin in the ECM also to boost its affinity for endocytic receptors like the lipoprotein receptor-related protein (LRP) in response to PA binding [33,39-43]
PAI-1 may represent an integral molecule in the quick connection/detachment occasions necessary for cell migration, by its capability to both lower its affinity for vitronectin in the ECM also to…