The coefficients of variation of inter-spike intervals (S6A Fig) were consistent between the experiment and the model, as was the trend that spontaneous activity and drifting gratings produced lower values than natural movies

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The coefficients of variation of inter-spike intervals (S6A Fig) were consistent between the experiment and the model, as was the trend that spontaneous activity and drifting gratings produced lower values than natural movies. a single background resource. The distribution of synapse figures over all background connections is demonstrated, combined from your three independent models. (d) Distribution of maximum somatic EPSC ideals for E-to-E recurrent connections in all simulated models (for biophysical neurons), within the log level. Data for three models per system type (LL, LR, RL, or RR) are demonstrated (see Main Text).(TIF) pcbi.1006535.s001.tif (387K) GUID:?9B9F2BCE-2E81-44D0-A424-991B8443BF94 S2 Fig: Features of PSPs and PSCs for the recurrent connections. Observe Online Methods for details of package plots. The features are voltage or current peak (peak), time from spike to peak (t_to_peak), rise time (t_rise), decay time (t_decay) and the PSP or PSC width (t_width). (a) Somatic PSP features. (b) Somatic PSC features. For each feature and each model type (i.e., LL, LR, RL, or RR), the sample sizes are n = 900 for E-to-E and I-to-E and Neurog1 n = 600 for E-to-I Ampiroxicam and I-to-I.(TIF) pcbi.1006535.s002.tif (1.6M) GUID:?A2AB9131-28EF-4D11-9AF3-391B5DDD9886 S3 Fig: Visual stimuli. Examples of visual stimuli utilized for simulations and experiments are demonstrated, such as (a) drifting gratings, (b) natural movies, (c) static natural images, (d) moving white or black bars, and (e) full-field flashes.(TIF) pcbi.1006535.s003.tif (1.3M) GUID:?EEEDF868-55B9-4220-9448-BF1CAE84A143 S4 Fig: Responses to moving bars. (a) Reactions of each biophysical neuron in one model to black and white bars; either a vertical pub was moving in a horizontal direction (Ori 0 degrees) or a horizontal pub was moving in a vertical direction (Ori 90 degrees). The reactions shown were from time-dependent firing rates (in 50 ms bins) averaged total trials of a given stimulus; the maximum total bins is definitely computed for each neuron. The neuron Ampiroxicam IDs for each type are arranged according to the neurons assumed direction preference for gratings (observe Online Methods), from 0 degrees for the 1st ID of a type to 360 degrees for the last (hence the pseudo-periodicity apparent in the plots). The types are Scnn1a (IDs 0 to 3699), Rorb (3700 to 6999), Nr5a1 (7000 to 8499), PV1 (8500 to 9299), and PV2 (9300 to 9999). (b) The difference Ori between the preferred orientations of a neuron relating to reactions to gratings and to bars, averaged total excitatory neurons that prefer 0, 90, 180, or 270 degrees for gratings. The averages and standard deviations are precisely zero for those three models tested. (c) Spike rasters (remaining) for biophysical neurons from pilot simulations of reactions to a horizontally moving white pub, using different model layouts illustrated on the right. For each spike, the position of the neuron along the x dimensions (which coincides with the direction of the moving bar) is definitely plotted versus spike time. Top, a model without LIF neurons, with biophysical neurons limited to a rectangular area, and using periodic boundary conditions for connectivity. Bottom, a model with biophysical neurons limited to a cylinder, with LIF neurons distributed in the periphery (no periodic boundary conditions)Cthat is definitely, the model layout chosen for those simulations reported in the Main Text. The approximate degree of the receptive fields (RFs) of LGN cells that feed into the biophysical portion of the model are designated by white dashed lines. Note that in these initial test simulations, the guidelines of the moving pub (its width and rate) were somewhat different from those chosen later on for production simulations.(TIF) pcbi.1006535.s004.tif (3.7M) GUID:?E7EE13E9-D4E3-4DE3-BBED-153626C9CAB1 S5 Fig: Additional characteristics of visual responses. (a) Distributions of skewness of firing rates. Left, simulation; Ampiroxicam right, electrophysiological experimental recordings. (b) The PSTHs from experimental electrophysiological recordings in response to a 50 ms adobe flash (average total L4 excitatory cells or all inhibitory cells recorded, and all tests, in 2 ms bins). (c) Example tuning curves of a single Scnn1a or PV1 cell to drifting gratings at contrasts C = 80% and C = 10%. For the Scnn1a cell, reactions normalized to the peak of the tuning curve will also be shown (middle). The data are averages over 10 tests. Error bars: standard deviation. Dashed lines: spontaneous rate (it is close to zero for the example Scnn1a cell demonstrated). (d) Summary of responses to the gratings at different contrasts (C = 30% or 10% Ampiroxicam vs. C = 80%). The distributions of variations HWHH = HWHH(C = 80%)HWHH(C = 30%) (top) and HWHH = HWHH(C = 80%)HWHH(C = 10%) (bottom), are demonstrated for those excitatory cells, with the average +/- standard deviation indicated. (e) Same as (d) for the variations of OSI for excitatory (reddish) and inhibitory (blue) neurons.(TIF) pcbi.1006535.s005.tif.