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Faraco for reading and commenting around the manuscript. to dyskineticCdystonic movements or stereotypies) motor disturbances. Active and negative motor scores correlated positively with the presence of hypotonic features at neurological examination and negatively with disease duration, whereas unfavorable motor scores also correlated negatively with age at disease onset. These observations suggest that paediatric narcolepsy with cataplexy often co-occurs with a complex movement disorder at disease CBL0137 onset, a phenomenon that may vanish later in the course of the disease. Further studies are warranted to assess clinical course and whether the associated movement disorder is also caused by hypocretin deficiency or by additional neurochemical abnormalities. alterations of the human striatal dopaminergic system in adult narcolepsy with cataplexy, and a significant impact of stimulant treatment on dopaminergic transmission (Staedt online. Rabbit Polyclonal to DIDO1 Supplementary Data: Click here to view. Acknowledgements We thank J. Faraco CBL0137 for reading and commenting around the CBL0137 manuscript. We are indebted to all the CBL0137 participants of the study, most notably the Italian association of narcoleptic patients (Associazione Italiana Narcolettici). Without their contributions, this study would not have been possible. Glossary AbbreviationsHLA??human leucocyte antigenPANDAS??paediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsREM??rapid eye movement.