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Basophil sensitivity is also useful for measuring response to AIT. document was synthesized and examined by all authors for consensus. Results: The ICAR:AR document addresses over 100 individual topics related to AR, including analysis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy screening modalities, treatment, and additional conditions/comorbidities associated with AR. Summary: This crucial review of the AR literature has identified several strengths; providers can be Cortisone assured that treatment decisions are supported by rigorous studies. LRIG2 antibody However, there are also considerable gaps in the AR literature. These knowledge gaps should be considered opportunities for improvement, as often the things that we educate and the medicine that we practice are not based on the best quality evidence. This document seeks to spotlight the advantages and weaknesses of the AR literature to identify areas for future AR study and improved understanding. Keywords: allergen draw out, allergy, allergen immunotherapy, sensitive rhinitis, antihistamine, asthma, atopic dermatitis, avoidance, biologic, cockroach, conjunctivitis, consensus, corticosteroid, cough, cromolyn, decongestant, eosinophilic esophagitis, environment, epicutaneous immunotherapy, epidemiology, evidence-based medicine, food allergy, genetics, house dust mite, Cortisone IgE, immunoglobulin E, immunotherapy, inhalant allergy, leukotriene, microbiome, occupational rhinitis, omalizumab, pathophysiology, perennial, pet dander, pollen, probiotic, quality of life, rhinitis, rhinosinusitis, risk element, saline, seasonal, sensitization, sinusitis, sleep, socioeconomic, specific IgE, subcutaneous immunotherapy, sublingual immunotherapy, systematic review, rhinitis, total IgE, transcutaneous immunotherapy, validated survey I.?Intro The available literature on allergic rhinitis (AR) grows more quickly with each passing decade. A search of sensitive rhinitis in the PubMed database yielded 4135 content articles published between 1945 and 1979. The next 20 years (1980-2000) saw 7064 AR content articles published. Each subsequent decade offers surpassed this quantity with 8143 AR content articles published between 2000 and 2010, and 8212 published from 2010 to the present day. Like many other areas of medicine, a detailed look at the available literature demonstrates a wide variance in the type and quality of AR publications, ranging from case reports to meta-analyses, review content articles to randomized controlled tests (RCTs), and large prospective studies to small retrospective case series. Like a medical professional reads the literature or hears literature quoted by others, it is important that he/she understand the quality of the evidence in order to appropriately translate the findings and recommendations into daily medical care of the AR Cortisone patient. With such vast AR literature available, developing an appropriate understanding of the relevant evidence can be daunting. This International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) was developed to summarize the best external evidence relating to AR, with the goal of gathering and critically critiquing the available literature on AR epidemiology, risk factors, analysis, management, and connected conditions/comorbidities. More than 100 international authors from numerous specialties utilized a organized review process to evaluate the evidence related to AR. Initial topic development and writing by a main author or team of authors, followed by a stepwise anonymous iterative review process for over 100 AR topics held this process to extremely high requirements. The resulting document provides a strong review of the existing AR literature. The recommendations for AR diagnostic modalities and treatment contained herein rely directly on this evidence, having a obvious delineation of the benefit, harm, and cost considerations that supported each recommendation level. Like the 2016 International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS) by Orlandi et al.,1 this ICAR:AR document places high value on the strength of the evidence in making recommendations. Therefore, for example, expert opinion receives lower value (Table II.A-1). You will find limitations, however. Like ICAR:RS, this document is not a medical practice guideline (CPG) or a meta-analysis. This document summarizes the findings of meta-analyses and additional systematic evaluations when those are recognized in the literature for a specific AR topic area. However, a meta-analysis was not performed on the data included in this document. In addition, much of the available AR literature is not appropriate for meta-analysis due to its heterogeneous nature and inconsistent methodologies. ICAR:AR.