(F) Representative histograms (still left) and quantification (correct) of PD-L1 expression by tumor-associated LECs in B16F10-OVA tumorCbearing mice receiving, or not, in vitroCactivated OT-I TCR-Tg Compact disc8+ T cells transferred 10 d after implantation adoptively

(F) Representative histograms (still left) and quantification (correct) of PD-L1 expression by tumor-associated LECs in B16F10-OVA tumorCbearing mice receiving, or not, in vitroCactivated OT-I TCR-Tg Compact disc8+ T cells transferred…

Continue Reading(F) Representative histograms (still left) and quantification (correct) of PD-L1 expression by tumor-associated LECs in B16F10-OVA tumorCbearing mice receiving, or not, in vitroCactivated OT-I TCR-Tg Compact disc8+ T cells transferred 10 d after implantation adoptively

At steady condition, we discovered that adipose tissues iNKT cells absence IL-7R and express high levels of Nur77 and Compact disc69, that are hallmarks of activation through TCR stimulation43

At steady condition, we discovered that adipose tissues iNKT cells absence IL-7R and express high levels of Nur77 and Compact disc69, that are hallmarks of activation through TCR stimulation43. phenotype…

Continue ReadingAt steady condition, we discovered that adipose tissues iNKT cells absence IL-7R and express high levels of Nur77 and Compact disc69, that are hallmarks of activation through TCR stimulation43

VerCINI experiments were performed on cells inside a mutant background, preventing unwanted cell rotation inside the microholes by disabling flagellar motility

VerCINI experiments were performed on cells inside a mutant background, preventing unwanted cell rotation inside the microholes by disabling flagellar motility. Microfluidic VerCINI Device set up Open-topped microhole coverslips were…

Continue ReadingVerCINI experiments were performed on cells inside a mutant background, preventing unwanted cell rotation inside the microholes by disabling flagellar motility

Specific anti-TGF- blocking antibodies or Galunisertib were widely used in these studies, being useful tools to demonstrate that NKG2D down-regulation is mainly mediated by this cytokine [30,32,37,39,46,47]

Specific anti-TGF- blocking antibodies or Galunisertib were widely used in these studies, being useful tools to demonstrate that NKG2D down-regulation is mainly mediated by this cytokine [30,32,37,39,46,47]. I ILC (ILC1).…

Continue ReadingSpecific anti-TGF- blocking antibodies or Galunisertib were widely used in these studies, being useful tools to demonstrate that NKG2D down-regulation is mainly mediated by this cytokine [30,32,37,39,46,47]